IU football has a chance to keep the first time ever, first time since train rolling in 2026.
The Hoosiers haven’t won a game against Michigan in Ann Arbor since 1967, and the program has never won against USC.
Ending those streaks won’t be easy this season.
USC is No. 13 in ESPN’s preseason FPI, and Michigan No. 15. On paper they are the second and third most difficult games on IU’s schedule.
But the odds are currently in IU’s favor to come away from those contests victorious.
Indiana travels to Ann Arbor on Oct. 24 to face the Wolverines at Michigan Stadium. IU’s last win at the 100,000+ seat monstrosity came as part of their 1967 run to a share of the Big Ten title and the Rose Bowl.
DraftKings has posted an early betting line for that game and has IU as a 6.5-point favorite over Michigan.
A few weeks later, IU will host USC on Nov. 14. The Hoosiers are 0-4 all-time against the Trojans, including a defeat in that Rose Bowl following the 1967 season. The teams last met in 1982. DraftKings currently likes Indiana to defeat USC by 10.5 points.
As an interesting side note, USC is one of just three Big Ten teams Indiana does not own an active winning streak against. The other two are also on IU’s 2026 schedule: Minnesota and Rutgers. What all three have in common is Indiana hasn’t played them since Curt Cignetti was hired. And If the Hoosiers can run the table in the league for a second straight year, they’ll own active winning streaks against all 18 teams.
There are also early betting odds for the season opener on Sept. 5. Indiana is a 40.5-point favorite against North Texas.
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